Match the Column 1 with Column 2 :

a-ii; b-iv; c-iii; d-i

The correct answer is Option (1)- a-ii; b-iv; c-iii; d-i

 Matching Column 1 with Column 2:

(a) Down's Syndrome - (ii) Trisomy 21 : Down's Syndrome is a genetic disorder characterized by the presence of an extra copy of chromosome 21, resulting in a total of three copies (trisomy) of this chromosome.

(b) Turner's Syndrome - (iv) 45 with XO : Turner's Syndrome occurs due to a chromosomal abnormality where a female is born with only one X chromosome (45,XO).

(c) Klinefelter's Syndrome - (iii) Karyotype of 47 ,XXY : Klinefelter's Syndrome is characterized by the presence of an extra X chromosome in males, resulting in a karyotype of 47,XXY.

(d) Thalassemia - (i) Mendelian Disease : Thalassemia refers to a group of inherited blood disorders caused by mutations in the genes that produce hemoglobin and is considered a Mendelian genetic disorder due to its inheritance patterns.

Therefore: (a) - (ii) , (b) - (iv), (c) - (iii), (d) - (i)