Practicing Success
What happened when heat-killed S cells along with R cells were injected into mice in Griffith's experiment? |
Mice died and showed live R cells in the blood Mice survived and showed live S cells in the blood Mice died and showed live S cells in the blood Mice survived and showed live R cells in the blood |
Mice died and showed live S cells in the blood |
The correct answer is Option (3) -Mice died and showed live S cells in the blood In 1928, Frederick Griffith, in a series of experiments with Streptococcus pneumoniae (bacterium responsible for pneumonia), witnessed a miraculous transformation in the bacteria. During the course of his experiment, a living organism (bacteria) had changed in physical form. When Streptococcus pneumoniae (pneumococcus) bacteria are grown on a culture plate, some produce smooth shiny colonies (S) while others produce rough colonies (R). This is because the S strain bacteria have a mucous (polysaccharide) coat, while R strain does not. Mice infected with the S strain (virulent) die from pneumonia infection but mice infected with the R strain do not develop pneumonia. S strain → inject into mice → Mice died R strain → inject into mice → Mice live Griffith was able to kill bacteria by heating them. He observed that heat-killed S strain bacteria injected into mice did not kill them. When he injected a mixture of heat-killed S and live R bacteria, the mice died. Moreover, he recovered living S bacteria from the dead mice. S strain → inject into mice → Mice live (heat-killed)
S strain (heat-killed) + → inject into mice → Mice die R strain (live) |