Which of the following is NOT a disease caused by a virus?

Plague

The correct answer is Option (2) -Plague

The correct option is "Plague."

Plague, caused by the bacterium Yersinia pestis, is not a disease caused by a virus. Plague is a serious bacterial infection that primarily affects rodents but can be transmitted to humans through the bite of infected fleas or through direct contact with infected animals or their tissues.

1. AIDS (Acquired Immunodeficiency Syndrome): AIDS is caused by the human immunodeficiency virus (HIV), which attacks the immune system, leading to a weakening of the body's defenses against infections and other diseases.
2. Zika: Zika virus is a mosquito-borne virus that primarily spreads through the bite of infected Aedes mosquitoes.
3. Ebola: Ebola virus disease (EVD) is caused by the Ebola virus and is transmitted to humans through direct contact with the bodily fluids of infected individuals or through contact with contaminated surfaces or materials.

In summary, while AIDS, Zika, and Ebola are all diseases caused by viruses, plague is caused by a bacterium and not a virus.