The Hoffmann bromamide degradation reaction is used for conversion of
Answer & explanation
Correct answer: option 2
The correct answer is Option (2) → Amide to amine
Hoffmann Bromamide Degradation Reaction:
It is used to convert a carboxylic acid amide (R–CONH₂) into a primary amine (R–NH₂) with one carbon less.
Reaction: R–CONH₂ + Br₂ + 4NaOH → R–NH₂ + Na₂CO₃ + 2NaBr + 2H₂O
Example: CH₃CONH₂ (acetamide) → CH₃NH₂ (methylamine)
Why others are wrong:
- Nitro to amine → Reduction (Sn/HCl or Fe/HCl)
- Cyanide to amine → Stephen reaction or reduction
- Amine to diazonium salt → Only primary aromatic amines with NaNO₂/HCl