Target Exam

CUET

Subject

Biology

Chapter

Biotechnology and its Applications

Question:

Read the paragraph given below and answer the question.

If a person is born with a hereditary disease, can a corrective therapy be taken for such a disease? Gene therapy is an attempt to do this. Gene therapy is a collection of methods that allows correction of a gene defect that has been diagnosed in a child/embryo. Here genes are inserted into a person's cells and tissues to treat disease.

ADA deficiency is caused due to:

Options:

Deficiency of bone marrow

Deletion of gene for adenosine diaminase

Addition of Adenosine

Deletion of amino group in genome

Correct Answer:

Deletion of gene for adenosine diaminase

Explanation:

The correct answer is Option (2) → Deletion of gene for adenosine diaminase

Gene therapy is a collection of methods that allows correction of a gene defect that has been diagnosed in a child/embryo. Here genes are inserted into a person’s cells and tissues to treat a disease.

Correction of a genetic defect involves delivery of a normal gene into the individual or embryo to take over the function of and compensate for the non-functional gene. The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency.

This enzyme is crucial for the immune system to function. The disorder is caused due to the deletion of the gene for adenosine deaminase.