Read the given passage carefully and answer the questions.

Salmonella typhi is a pathogenic bacterium which causes typhoid fever in human beings. Sustained high fever (39° to 40°C), weakness, stomach pain, constipation, headache and loss of appetite are some of the common symptoms of this disease. Typhoid fever could be confirmed by Widal test. Plasmodium enters the human body as sporozoites. The parasites initially multiply within the liver cells and then attack the red blood cells (RBCs) resulting in their rupture. The rupture of RBCs is associated with release of a toxic substance, haemozoin, which is responsible for the chill and high fever recurring every three to four days. There is lymphoid tissue also located within the lining of the major tracts (respiratory, digestive and urogenital tracts) called mucosa-associated lymphoid tissue (MALT). In our body, cell growth and differentiation is highly controlled and regulated. In cancer cells, there is breakdown of regulatory mechanisms. Normal cells show a property called contact inhibition by virtue of which contact with other cells inhibits their uncontrolled growth. Cancerous cells just continue to divide giving rise to masses of cells called tumors. Tumors are of two types: benign and malignant. Cannabinoids are a group of chemicals, which interact with cannabinoid receptors present principally in the brain. Generally taken by inhalation and oral ingestion, these are known for their effects on cardiovascular system of the body.

In which organ of the human body, cannabinoid receptors are principally present?

Brain

The correct answer is Option (4) → Brain 

Cannabinoids are a group of chemicals that interact with cannabinoid receptors primarily found in the brain. They are naturally derived from the inflorescences of the plant Cannabis sativa, commonly known as marijuana or cannabis. The flower tops, leaves, and resin of the cannabis plant are used in various combinations to produce marijuana, hashish, charas, and ganja.

Cannabinoids are typically consumed through inhalation or oral ingestion. When consumed, they have known effects on the cardiovascular system of the body. These effects can vary depending on the specific cannabinoid and its concentration, as well as individual factors such as dosage, method of consumption, and individual tolerance.

It's important to note that the use of cannabinoids, particularly marijuana, for recreational or medicinal purposes is subject to legal regulations in many countries. The effects and potential risks associated with the use of cannabinoids can vary among individuals, and their use should be approached with caution and in compliance with applicable laws and regulations.