Select the wrong statement(s) with respect to HIV

A. HIV belongs to retrovirus group.

B. HIV infection can occur by transfusion of contaminated blood and blood products.

C. In macrophages, viral DNA is produced by reverse transcription.

D. HIV enter into B-lymphocytes, replicate and produce progeny.

Choose the correct answer from the options given below:

D only

The correct answer is Option (3) -  D only .HIV enters into B-lymphocytes, replicates, and produces progeny.

HIV primarily infects CD4+ T-lymphocytes and not B-lymphocytes. B-lymphocytes are not the primary target cells for HIV infection.

Here's an explanation for each statement:

A. HIV belongs to retrovirus group. This statement is correct. HIV, or Human Immunodeficiency Virus, belongs to the retrovirus group. Retroviruses are a family of RNA viruses that are known for their ability to reverse transcribe their RNA genome into DNA, which then becomes integrated into the host cell's genome.

B. HIV infection can occur by transfusion of contaminated blood and blood products. This statement is correct. Transmission of HIV-infection generally occurs by (a) sexual contact with infected person, (b) by transfusion of contaminated blood and blood products, (c) by sharing infected needles as in the case of intravenous drug abusers and (d) from infected mother to her child through placenta.

C. In macrophages, viral DNA is produced by reverse transcription. This statement is correct. In macrophages and other target cells, the HIV RNA genome is reverse-transcribed into DNA by the viral enzyme reverse transcriptase. This newly formed viral DNA is then integrated into the host cell's genome, allowing the virus to establish a latent infection.

D. HIV enters into B-lymphocytes, replicates, and produces progeny. This statement is incorrect. HIV primarily infects CD4+ T-lymphocytes (a type of immune cell) and not B-lymphocytes. CD4+ T-cells are the primary target cells for HIV infection. HIV does not typically enter B-lymphocytes, replicate within them, or produce progeny in these cells. Instead, B-lymphocytes are primarily involved in the humoral immune response and the production of antibodies.