Select the wrong statement(s) with respect to HIV
A. HIV belongs to retrovirus group.
B. HIV infection can occur by transfusion of contaminated blood and blood products.
C. In macrophages, viral DNA is produced by reverse transcription.
D. HIV enter into B-lymphocytes, replicate and produce progeny.
Choose the correct answer from the options given below:
Answer & explanation
Correct answer: option 3
The correct answer is Option (3) → D only
A. HIV belongs to retrovirus group. — True. HIV has an RNA genome copied into DNA by reverse transcriptase.
B. HIV infection can occur by transfusion of contaminated blood and blood products. — True.
C. In macrophages, viral DNA is produced by reverse transcription. — True. The infected macrophage keeps making virus, acting like an HIV factory.
D. HIV enter into B-lymphocytes, replicate and produce progeny. — False. HIV enters helper T-lymphocytes, not B-lymphocytes.
NCERT Extract:
AIDS – “AIDS is caused by the Human Immuno deficiency Virus (HIV), a member of a group of viruses called retrovirus, which have an envelope enclosing the RNA genome (Figure 7.6). Transmission of HIV-infection generally occurs by (a) sexual contact with infected person, (b) by transfusion of contaminated blood and blood products, … After getting into the body of the person, the virus enters into macrophages where RNA genome of the virus replicates to form viral DNA with the help of the enzyme reverse transcriptase. This viral DNA gets incorporated into host cell’s DNA and directs the infected cells to produce virus particles (Figure 7.6). The macrophages continue to produce virus and in this way acts like a HIV factory. Simultaneously, HIV enters into helper T-lymphocytes (TH), replicates and produce progeny viruses. The progeny viruses released in the blood attack other helper T-lymphocytes. This is repeated leading to a progressive decrease in the number of helper T-lymphocytes in the body of the infected person.”
