In most of the paintings, produced from the time that the Europeans were in contact with the court of Akbar, we can see an increasing preference for a category of naturalism adapted to compliment the growing diversity in medieval India. Madonna and Child (1580) done in opaque watercolour on paper is an important early work of the Mughal School of Painting in this context. Madonna, here, is an extraordinary theme, which brings the Byzantine art, the European classical and its Renaissance to the Mughal atelier, where it is translated and transformed into an entirely different visual experience. Virgin Mary is draped in a classical manner. The attachment displayed between the mother and the child was inspired by the humanist interpretation in the European Renaissance art. The physiology of the child, certain details like the fan and jewellery completely integrated the work to an Indian milieu.

What is the significant theme of the painting "Madonna and Child (1580)" in the context of the Mughal School of Painting?

European classical and Renaissance themes are incorporated

Answer:  European classical and Renaissance themes
The painting "Madonna and Child (1580)" incorporates European classical and Renaissance themes into the Mughal School of Painting.

In most of the paintings, produced from the time that the Europeans were in contact with the court of Akbar, we can see an increasing preference for a category of naturalism adapted to compliment the growing diversity in medieval India. Madonna and Child (1580) done in opaque watercolour on paper is an important early work of the Mughal School of Painting in this context. Madonna, here, is an extraordinary theme, which brings the Byzantine art, the European classical and its Renaissance to the Mughal atelier, where it is translated and transformed into an entirely different visual experience. Virgin Mary is draped in a classical manner. The attachment displayed between the mother and the child was inspired by the humanist interpretation in the European Renaissance art. The physiology of the child, certain details like the fan and jewellery completely integrated the work to an Indian milieu.