Assertion: Using biotechnology human insulin can be produced into bacterial cells.
Reason :To produce human insulin the A, B and C polypeptides of the human insulin are produced in the bacterial cells, separately extracted and combined by creating disulfide bonds.

Assertion (A) is true but Reason (R) is not correct.

Adult onset diabetes management is possible by taking insulin at regular time intervals, but insulin from other animals could elicit immune response in body. Biotechnology has helped to overcome this problem. Transgenic bacteria have been produced that translate the constituting polypeptide chains of human insulin from the bacterial cells. These polypeptides can be extracted and combined to produce human insulin, by creating disulfide bonds. In humans, insulin is produced as a prohormone with three polypeptides A, B and C. After processing, the C peptide is removed and mature insulin is formed. When transgenic bacteria are used, instead of producing extra stretch of C peptide, only A and B polypeptides are produced and then linked directly to produce mature insulin.