Match List I with List II

 Choose the correct answer from the options given below:

A-III, B-IV, C-I, D-II

The correct answer is Option (1)- A-III, B-IV, C-I, D-II

Bacillus thuringiensis (Bt) is a bacterium that produces proteins called Bt toxins, which are toxic to certain insects. Specific Bt toxin genes were isolated from Bacillus thuringiensis and incorporated into the several crop plants such as cotton .
The choice of genes depends upon the crop and the targeted pest, as most Bt toxins are insect-group specific. The toxin is coded by a gene cryIAc named cry.

Using Agrobacterium vectors, nematode-specific genes were introduced into the host plant . The introduction of DNA was such that it produced both sense and anti-sense RNA in the host cells.

Eli Lilly an American Company in 1983 started selling humulin. They prepared two DNA sequences corresponding to A and B , chains of human insulin and introduced them in plasmids like pBR322 and then transformed E.coli to produce insulin chains.

Gene therapy involves introducing genetic material into a person's cells to treat or prevent disease. In the context you provided, lymphocytes (a type of white blood cell) are taken from a patient's blood and grown in a culture outside the body. Then, a functional ADA (adenosine deaminase) cDNA (complementary DNA) is introduced into these lymphocytes using a retroviral vector.