Practicing Success

Target Exam

CUET

Subject

Biology

Chapter

Principles of Inheritance and Variation

Question:

Read the given passage and answer the questions that follow :-
Thalassemia is a mendelian disorder. It is basically a blood disease transmitted from parents to the off spring when both the partners are unaffected career for the gene. The defect could be due to either mutation or deletion which ultimately results in reduced rate of synthesis of one of the globin chains that make up haemoglobin.

What kind of mendelian disorder is thalassemia?

Options:

Autosomal recessive

Autosomal dominant

Sex linked recessive

None of these

Correct Answer:

Autosomal recessive

Explanation:

Thalassemia  is an autosome-linked recessive blood disease transmitted from parents to the offspring when both the partners are unaffected carrier for the gene (or heterozygous). The defect could be due to either mutation or deletion which ultimately results in reduced rate of synthesis of one of the globin chains (α and β chains) that make up haemoglobin. This causes the formation of abnormal haemoglobin molecules resulting into anaemia which is characteristic of the disease.