Match List I with List II :

Choose the correct answer from the options given below:

A-III, B-IV, C-I, D-II

The correct answer is Option (4) - A-III, B-IV, C-I, D-II

A. In 1928, Frederick Griffith, in a series of experiments with Streptococcus pneumoniae (bacterium responsible for pneumonia), witnessed a miraculous transformation in the bacteria. He concluded that the R strain bacteria had somehow been transformed by the heat-killed S strain bacteria. Some ‘transforming principle’, transferred from the heat-killed S strain, had enabled the R strain to synthesise a smooth polysaccharide coat and become virulent. This must be due to the transfer of the genetic material.

B. The lac operon is a group of genes through which Escherichia coli catabolizes lactose. It was first proposed by F. Jacob and J. Monod, who were also awarded the Nobel Prize in Physiology or Medicine in 1965 for their contributions.

C. The chemical method developed by Har Gobind Khorana was instrumental in synthesising RNA molecules with defined combinations of bases (homopolymers and copolymers).Khorana deciphering the genetic code that translates DNA sequences into the protein molecules that carry out the functions of living cells

D. Meselson and Stahl Experiment was an experimental proof for semiconservative DNA replication. In 1958, Matthew Meselson and Franklin Stahl conducted an experiment on Escherichia coli which divides in 20 minutes, to study the replication of DNA.