Practicing Success

Target Exam

CUET

Subject

Biology

Chapter

Biotechnology and its Applications

Question:
Gene therapy could be a permanent cure when :
Options:
The gene isolate from marrow cells producing ADA is introduced into cells at early embryonic stages.
The gene isolate from liver producing ADA is introduced into cells at late embryonic stages.
The gene isolate from teenage and treated.
Using rDNA and EcoR I.
Correct Answer:
The gene isolate from marrow cells producing ADA is introduced into cells at early embryonic stages.
Explanation:
In gene therapy , lymphocytes from the blood of the patient are grown in a culture outside the body. A functional ADA cDNA (using a retroviral vector) is then introduced into these lymphocytes, which are subsequently returned to the patient. However, as these cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes. However, if the gene isolate from marrow cells producing ADA is introduced into cells at early embryonic stages, it could be a permanent cure.