Among the options provided, "Handshake" is NOT a mode of transmission for AIDS (Acquired Immunodeficiency Syndrome).

AIDS is primarily transmitted through:

1. Unprotected sexual intercourse with an infected person, especially if there are open sores or mucous membrane tears.
2. Sharing contaminated needles or syringes, typically associated with intravenous drug use.
3. Mother-to-child transmission during childbirth or breastfeeding.
4. Contaminated blood transfusions or organ transplants from infected donors (though this risk is minimized due to rigorous testing of blood and organs).

Casual contact such as handshakes, hugs, or sharing items like utensils or clothes does not transmit the human immunodeficiency virus (HIV), which causes AIDS. HIV is not spread by saliva, sweat, or casual contact in daily interactions. It requires direct exposure to certain bodily fluids carrying the virus for transmission to occur.