Match List I with List II
|
LIST I |
LIST II |
|
A. Alec Jeffreys |
I. Operon model |
|
B. Jacob and Monod |
II. X-ray diffraction data of DNA |
|
C. Erwin Chargaff |
III. DNA Fingerprinting |
|
D. Wilkins and Franklin |
IV. $\frac{A+G}{T+C}=1$ |
Choose the correct answer from the options given below:
Answer & explanation
Correct answer: option 2
The correct answer is Option (2) → A-III, B-I, C-IV, D-II
|
LIST I |
LIST II |
|
A. Alec Jeffreys |
III. DNA Fingerprinting |
|
B. Jacob and Monod |
I. Operon model |
|
C. Erwin Chargaff |
IV. $\frac{A+G}{T+C}=1$ |
|
D. Wilkins and Franklin |
II. X-ray diffraction data of DNA |
A. The technique of DNA Fingerprinting was initially developed by Alec Jeffreys. He used a satellite DNA as probe that shows very high degree of polymorphism. It was called as Variable Number of Tandem Repeats (VNTR).
B. In 1961, two French microbiologists,Francois Jacob and Jacque Monod at the Pasteur Institute, Paris proposed a mechanism,called operon hypothesis, for the regulation of gene action as a result of their studies on the metabolism in E.coli.
C. The double helix model for the structure of DNA involves base pairing between the two strands of polynucleotide chains. This proposition was also based on the observation of Erwin Chargaff that for a double stranded DNA, the ratios between Adenine and Thymine and Guanine and Cytosine are constant and equals one.
D. DNA as an acidic substance present in nucleus was first identified by Friedrich Meischer in 1869. He named it as ‘Nuclein’. It was only in 1953 that James Watson and Francis Crick, based on the X-ray diffraction data produced by Maurice Wilkins and Rosalind Franklin, proposed a very simple but famous Double Helix model for the structure of DNA.