Select the most appropriate meaning of the given idiom.

Lose your marbles

To go insane

The most appropriate meaning of the idiom "lose your marbles" is to go insane.

It is a colloquial expression that means to become very angry or upset, to the point of losing control. It is often used to describe someone who is behaving in a irrational or unpredictable way.

The other options are incorrect:

• To handle stress: This is not the meaning of the idiom "lose your marbles."
• To lower down anger: This is not the meaning of the idiom "lose your marbles."
• To be patient: This is the opposite of the meaning of the idiom "lose your marbles."