In case of malaria, the rupture of RBCs is associated with release of a toxic substance called _________________, responsible for the chill and high fever recurring after every three to four days.

Haemozoin

The correct answer is Option (2) → Haemozoin

Plasmodium falciparum is a malaria parasite associated with severe cases of malaria. Malaria is a parasitic disease that involves high fevers, shaking chills, flu-like symptoms, and anemia. In malaria, the product released by mosquito into the blood that causes chill and fever is called Haemozoin. Haemozoin is formed from the digestion of blood by some blood-feeding parasites. Malarial parasite after entering the blood ruptures red blood cells and releases a toxin called hemozoin.