The correct answer is Option (4) –Both 1 and 3.
Sickle-cell anemia and thalassemia are autosomal recessive disorders, while Klinefelter's syndrome is a chromosomal disorder caused by the presence of an extra X chromosome in males (XXY).
Thalassemia is an autosome-linked recessive blood disease .Sickle-cell anaemia is also an autosome linked recessive trait . Most common and prevalent Mendelian disorders are Haemophilia, Cystic fibrosis, Sicklecell anaemia, Colour blindness, Phenylketonuria, Thalassemia, etc.
Therefore, the correct answer is option (4) - Both 1 (Sickle-cell anemia) and 3 (Thalassemia).