Match the Column I with Column II:
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A - iii, B - ii, C - i, D - iv A - iii, B - iv, C - i, D - ii A - ii, B - i, C - iii, D - iv A - iv, B - iii, C - ii, D - i |
A - iii, B - iv, C - i, D - ii |
The correct answer is Option (2) - A - iii, B - iv, C - i, D - ii
Colour blindness: Sex-linked recessive disorder caused due to mutation in genes present on X-chromosome. Mostly females are carrier while males contract the disease. Affected person fails to discriminate red and green colour. Haemophilia : Sex-linked recessive disorder which prevent clotting of blood. Heterozygote females are carrier who transmit the disease to sons. Thalassemia. Autosome linked recessive trait. α-thalassemia is caused due to the mutation in HBA1 and HBA2 genes on chromosome 16. β-thalassemia is caused due to the mutation in HBB gene on chromosome 11. The rate of synthesis of α or β-chain gets reduced leading to the formation of abnormal haemoglobin. Sickle-cell anaemia: Autosome linked recessive trait. Caused due to the substitution of glutamic acid by valine as the sixth codon of β-globin gene gets substituted from GAG to GUG. RBCs become sickle-shaped under low O2 tension. |