Target Exam

CUET

Subject

Biology

Chapter

Principles of Inheritance and Variation

Question:

Match the Column I with Column II:

Column I Column II
A. Colour blindness i. RBCs become sickle-shaped under low O₂ tension
B. Haemophilia ii. Mutation on HBA1 and HBA2 genes on chromosome 16 or HBB gene on chromosome 11, causing abnormal haemoglobin
C. Sickle-cell anaemia iii. Sex-linked recessive disorder where affected person cannot distinguish between red and green
D. Thalassemia iv. Sex-linked recessive disorder preventing blood clotting

 

Options:

A - iii, B - ii, C - i, D - iv

A - iii, B - iv, C - i, D - ii

A - ii, B - i, C - iii, D - iv

A - iv, B - iii, C - ii, D - i

Correct Answer:

A - iii, B - iv, C - i, D - ii

Explanation:

The correct answer is Option (2) - A - iii, B - iv, C - i, D - ii

Column I Column II
A. Colour blindness iii. Sex-linked recessive disorder where affected person cannot distinguish between red and green
B. Haemophilia iv. Sex-linked recessive disorder preventing blood clotting
C. Sickle-cell anaemia i. RBCs become sickle-shaped under low O₂ tension
D. Thalassemia ii. Mutation on HBA1 and HBA2 genes on chromosome 16 or HBB gene on chromosome 11, causing abnormal haemoglobin

Colour blindness:  Sex-linked recessive disorder caused due to mutation in genes present on X-chromosome. Mostly females are carrier while males contract the disease. Affected person fails to discriminate red and green colour.

Haemophilia :  Sex-linked recessive disorder which prevent clotting of blood. Heterozygote females are carrier who transmit the disease to sons.

Thalassemia.  Autosome linked recessive trait. α-thalassemia is caused due to the mutation in HBA1 and HBA2 genes on chromosome 16. β-thalassemia is caused due to the mutation in HBB gene on chromosome 11. The rate of synthesis of α or β-chain gets reduced leading to the formation of abnormal haemoglobin.

Sickle-cell anaemia:  Autosome linked recessive trait. Caused due to the substitution of glutamic acid by valine as the sixth codon of β-globin gene gets substituted from GAG to GUG. RBCs become sickle-shaped under low O2 tension.